Key Publications
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Smith L, Gonzalez Santiago E, Eke C, Gu W, Wang W, Llivichuzhca-Loja D, Kehoe T, St Denis K, Strine M, Taylor S, Tseng G, Konnikova L. Human milk supports robust intestinal organoid growth, differentiation, and homeostatic cytokine production. Gastro Hep Advances, 2024, ISSN 2772-5723, https://doi.org/10.1016/j.gastha.2024.07.007.
Gu W, Eke C, Gonzalez Santiago E, Olaloye O, Konnikova L. Single-cell atlas of the small intestine throughout the human lifespan demonstrates unique features of fetal immune cells. Mucosal Immunol. 2024 Aug;17(4):599-617. doi: 10.1016/j.mucimm.2024.03.011. Epub 2024 Mar 28. PMID: 38555026 Egozi A, Olaloye O, Werner L, Silva T, McCourt B, Pierce RW, An X, Wang F, Chen K, Pober JS, Shouval D, Itzkovitz S, Konnikova L. Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis. PLoS Biol. 2023 May 19;21(5):e3002124. doi: 10.1371/journal.pbio.3002124. eCollection 2023 May. PMID: 37205711 Toothaker JM, Olaloye O, McCourt BT, McCourt CC, Silva TN, Case RM, Liu P, Yimlamai D, Tseng G, Konnikova L. Immune landscape of human placental villi using single-cell analysis. Development. 2022 Apr 15;149(8). doi: 10.1242/dev.200013. Epub 2022 Feb 17. PubMed PMID: 35050308; PubMed Central PMCID: PMC8935213. Egozi A, Llivichuzhca-Loja D, McCourt BT, Bahar Halpern K, Farack L, An X, Wang F, Chen K, Konnikova L, Itzkovitz S. Insulin is expressed by enteroendocrine cells during human fetal development. Nat Med. 2021 Dec;27(12):2104-2107. doi: 10.1038/s41591-021-01586-1. Epub 2021 Dec 9. PubMed PMID: 34887578. Olaloye OO, Liu P, Toothaker JM, McCourt BT, McCourt CC, Xiao J, Prochaska E, Shaffer S, Werner L, Gringauz J, Good M, Goldsmith JD, An X, Wang F, Snapper SB, Shouval D, Chen K, Tseng G, Konnikova L. CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants. J Exp Med. 2021 Sep 6;218(9). doi: 10.1084/jem.20200344. Epub 2021 Jul 16. PubMed PMID: 34269788; PubMed Central PMCID: PMC8289692. Li Y, Toothaker JM, Ben-Simon S, Ozeri L, Schweitzer R, McCourt BT, McCourt CC, Werner L, Snapper SB, Shouval DS, Khatib S, Koren O, Agnihorti S, Tseng G, Konnikova L. In utero human intestine harbors unique metabolome, including bacterial metabolites. JCI Insight. 2020 Nov 5;5(21). doi: 10.1172/jci.insight.138751. PubMed PMID: 33001863; PubMed Central PMCID: PMC7710283. Mitsialis V, Wall S, Liu P, Ordovas-Montanes J, Parmet T, Vukovic M, Spencer D, Field M, McCourt C, Toothaker J, Bousvaros A, Shalek AK, Kean L, Horwitz B, Goldsmith J, Tseng G, Snapper SB, Konnikova L. Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease. Gastroenterology. 2020 Aug;159(2):591-608.e10. doi: 10.1053/j.gastro.2020.04.074. Epub 2020 May 16. PubMed PMID: 32428507; PubMed Central PMCID: PMC8166295. Toothaker JM, Presicce P, Cappelletti M, Stras SF, McCourt CC, Chougnet CA, Kallapur SG, Konnikova L. Immune Cells in the Placental Villi Contribute to Intra-amniotic Inflammation. Front Immunol. 2020;11:866. doi: 10.3389/fimmu.2020.00866. eCollection 2020. PubMed PMID: 32528468; PubMed Central PMCID: PMC7256198. Stras SF, Werner L, Toothaker JM, Olaloye OO, Oldham AL, McCourt CC, Lee YN, Rechavi E, Shouval DS, Konnikova L. Maturation of the Human Intestinal Immune System Occurs Early in Fetal Development. Dev Cell. 2019 Nov 4;51(3):357-373.e5. doi: 10.1016/j.devcel.2019.09.008. Epub 2019 Oct 10. PubMed PMID: 31607651. |