Liza Konnikova Lab
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  • Home
  • Principal Investigator
  • Lab Members
  • Research
  • Selected Publication
  • News
  • Contact
  • Yale website

Research Interests

Using cutting edge techniques such as mass cytometry (CyTOF) and single cell RNA sequencing (scRNAseq), my group is currently focused on studying  how mucosal immunity develops and what goes awry to cause disease.
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Immunobiology at the maternal-fetal interface

Using a combination of primary cells, organoids and primary tissue, we are investigating how immune dysregulation at the feto-maternal interface can contribute to preterm labor and other pregnancy complications.
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Intestinal immunity in health and disease

One of the main focuses of our group is to understand how mucosal homeostasis develops in infants and young children, particularly as it relates to development and maintenance of adaptive immunity. Using a combination of single cell techniques, we are studying intestinal immunity of  fetal, premature and term infants and pediatric subjects.
Furthermore, we are interested in determining how mucosal homeostasis becomes dysregulated in intestinal diseases such as necrotizing enterocolitis and inflammatory bowel disease.
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Immune regulation by microbial byproducts


As part of our studies related to development of mucosal immunity, we are interested in identifying factors such as bacterial metabolites that are involved in establishing and maintaining a healthy mucosal immune system.

Placental Organoids

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Clinical Interests

We are currently consenting for our research study to better understand how cell signals and receptors in the immune system vary in patients with inflammatory bowel disease (IBD).  We are also interested in uncovering changes in immune cell populations after IBD patients start treatment. 
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